The Pollard lab at Salk: moving the leading edge forward
نویسندگان
چکیده
منابع مشابه
Life at the Leading Edge
Cell migration requires sustained forward movement of the plasma membrane at the cell's front or "leading edge." To date, researchers have uncovered four distinct ways of extending the membrane at the leading edge. In lamellipodia and filopodia, actin polymerization directly pushes the plasma membrane forward, whereas in invadopodia, actin polymerization couples with the extracellular delivery ...
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Plasma membrane tension and the pressure generated by actin polymerization are two antagonistic forces believed to define the protrusion rate at the leading edge of migrating cells [1-5]. Quantitatively, resistance to actin protrusion is a product of membrane tension and mean local curvature (Laplace's law); thus, it depends on the local geometry of the membrane interface. However, the role of ...
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ژورنال
عنوان ژورنال: Biophysical Reviews
سال: 2018
ISSN: 1867-2450,1867-2469
DOI: 10.1007/s12551-018-0480-x